6° Giornata della Ricerca Clinica della Svizzera Italiana – 18 marzo 2016


 

1. Apertura ufficiale della 6° Giornata della Ricerca  – P. Martinoli, Presidente USI

2. Presentazioni Centri di ricerca in Ticino Chair: T. Moccetti / F. Barazzoni

CCMC Center of Computational Medicine in Cardiology e  ICS Institute of Computational Science
SIRM Swiss Institute of Regenerative Medicine
IOR Institute of Oncology Research
IRB Institute of Research in Biomedicine
NSI Neurocentro della Svizzera italiana
ICP Istituto Cantonale di Patologia (Video)

3. Key Note Lecture: Chair F. Cavalli

A. Alimonti, Capo Gruppo – Oncologia Molecolare IOR  – Dual targeting of Senescence and Tumor immunity for cancer therapy (Video)

 

ABSTRACTS

ONCOLOGIA
Preclinica
7 Bernasconi E. Evaluation of the novel BET Bromodomain inhibitor BAY-1238097 in lymphoma models
24 Chung EYL. ETS1-phosphorylation as novel potential tool for the cell-of-origin (COO) of diffuse large B-cell lymphoma (DLBCL)
50 Gaudio E. In vitro and in vivo activity of the BET Bromodomain inhibitor OTX015 (MK-8628) in mantle cell lymphoma (MCL)
51 Gaudio E. The BET Bromodomain inhibitor OTX015 (MK-8628) shows in vivo anti-tumor activity in combination with targeted agents in diffuse large B-cell lymphoma (DLBCL)
52 Gaudio E. The MEK-inhibitor pimasertib is synergistic with PI3K-delta and BTK inhibitors in lymphoma models
108 Tarantelli C. Bertoni F. An integrated phosphoproteomic approach to dissect the mechanism of action of the novel dual PI3K/mTOR inhibitor PQR309 in B-cell lymphomas
Clinica
26 Conconi A. Outcome analysis of diffuse large B-cell lymphomas in HIV and immunocompetent (IC) individuals
20 Ceriani L. VALORE PROGNOSTICO DEI PARAMETRI QUANTITATIVI DERIVATI DALLA 18FDG PET-CT ESEGUITA IN CONDIZIONI BASALI IN PAZIENTI CON LINFOMA DIFFUSO A GRANDI CELLULE B (DLBCL) (Studio ABREOC-08-002)
79 Paone G. Prognostic value of pre-treatment 18F-FDG PET/CT volumetric parameters in patients with locally advanced larynx carcinoma.
68 Martin V. Trastuzumab come opzione terapeutica nel carcinoma mammario HER2 equivoco? La scelta dell’oncologo.
71 Montagna G. Can we make a portrait of women with inoperable locally advanced breast cancer? The experience of the Breast Unit of Southern Switzerland (CSSI)
76 Pace M. DESIDERIO DI GRAVIDANZA IN PAZIENTI TRATTATE PER TUMORE CEREBRALE. IMPLICAZIONI CLINICHE E PSICO-SOCIALI.
115 Valcarenghi D. Infermieri oncologici: le loro decisioni di assistenza e la valutazione degli esiti per i pazienti.
CASE REPORT
8 Bianchi G. – Gabutti L. Primo caso di recidiva sotto trattamento con Eculizumab in paziente con malattia a depositi densi.
34 De Francesco M. Successful Management of Severe Hypernatraemia, Rhabdomyolysis and Acute Kidney Injury (AKI) with Hyper-osmolar Dialysate Solutions in Continuous Renal Replacement Therapy (CRRT)
35 De Francesco M. Automated Peritoneal Dialysis (APD) in Systemic Amyloidosis with amyloid infiltration of the peritoneum
38 Demarchi M. Endo/Exo-Prosthesis In A 51 Years Old Woman: First Case In Switzerland
64 Maino P. Koetsier E.Efficacious Dorsal Root Ganglion Stimulation for Painful Small Fiber Neuropathy: a Case Report
92 Rochat T. Floor of   the IVth ventricular melanocytoma: a rare tumor in an uncommon location
102 Schönholzer C. Recurrent Catastrophic Antiphospholipid Syndrome Treated with Eculizumab in a Peritoneal Dialysis Patient
121 Violo L. Schönholzer C. Unusual reddish-colored plasmapheresate: a Case Report
48 Gallo M. Transcatheter Heart Valve Implantation under Direct Vision in Rheumatic Calcified Mitral Valve
REVISIONE LETTERATURA
58 Helbling R. Porpora di Schönlein-Henoch complicata da pancreatite o colecistite alitiasica: revisione sistematica della letteratura
59 Kottanattu L. Colecistite e pancreatite in corso di mononucleosi infettiva da virus di Epstein-Barr nel soggetto immunocompetente
98 Santi M. Metabolismo del magnesio nella fibrosi cistica: revisione della letteratura
116 Valisena S. Treatment of Morton’s Neuroma: a Systematic Review
RADIOLOGIA
87 Pravatà E. Ongoing Research Project: “High-resolution post-contrast imaging at 3 Tesla, a comparison of three different techniques.”
17 Cattaneo M. Aterosclerosi carotidea umana in-vivo: correlazione tra la vascolarizzazione della placca all’ecografia con contrasto e l’ecogenicità della placca.
NEFROLOGIA
120 Violetti E. Schönholzer C. The first hemodialysis unit in a nursing home in Switzerland: experience of the first 4 years
46 Gabutti L. Valutazione dell’attivazione della coagulazione in 3 diversi filtri per emodialisi in polisulfone: uno studio in cross-over randomizzato controllato
ORTOPEDIA E RIABILITAZIONE
6 Barbero M. The relationship between pain extent and health status in whiplash associated disorders
62 Lehoczky Gy. Posizionamento percutaneo di viti sacro-iliache con navigazione mediante 3D-TAC (O-Arm©) nelle fratture dell’anello pelvico posteriore
101 Schneebeli A. Real-time sonoelastography using an external reference material: test–retest reliability on healthy Achilles tendon.
FARMACOLOGIA E PATOLOGIA
3 Andreocchi L. Farmacovigilanza attiva: sorveglianza elettronica delle reazioni avverse
 41 Epistolio S. A new Real-time PCR-based technology for a better identification of KRAS exon 3 mutations in CRC
Epistolio S. Characterization of NRAS in CRC patients: a faster and more sensitive Real-time PCR-based technology
45 Frattini M. Phase II explorative trial to prospectively investigate predictive molecular biomarkers for efficacy of panitumumab (P) in platinum-pretreated head and neck squamous cell cancer (HNSCC)(S10PANI01)
67 Mangas C. La predisposizione genetica al melanoma nella Svizzera italiana. Parte 2: implicazioni psicologiche e comportamentali dopo l’analisi genetica
EPATOCENTRO
36 De Gottardi A. Antithrombotic treatment with direct-acting oral anticoagulants (DOACs) in patients with portal hypertension
74 Moriggia A. Prospective data on People who use drugs in Switzerland: the SAMMSU cohort.
110 Terziroli B. The health burden of Primary Biliary Cholangitis in Switzerland – SwissPBC | SASL 36
CHIRURGIA
84 Peloni G. Paratiroidectomia mini-invasiva video-assistita: 15 anni di esperienza
119 Vignanelli M. Small gauge vitrectomy for symptomatic floaters: safety, efficacy and patient’s satisfaction.
NEUROCENTRO
Preclinica
44 Foglieni C. Search for pathogenic modifications of proteins involved in neurodegenerative disorders
96 Salvadè A. Cellular assays to study transneuronal propagation of tau pathology in neurodegenerative disorders
69 Melli G. Alpha-synuclein detection and characterization by skin biopsy: a novel biomarker for Parkinson’s Disease
75 Orban G. Galati S. Integration of cortical and basal ganglia inputs in motor thalamus of parkinsonian animal models
104 Sgroi S. Effect of Naltrindole on locomotor hypersensitivity to Levodopa treatment in parkinsonian rats
Clinica
65 Manconi M. Open-label study of the efficacy and safety of Intravenous Ferric Carboxymaltose in pregnant women with Restless Legs Syndrome
70 Miano S. Sleep disorders and epilepsy in attention deficit hyperactivity disorder: preliminary results of a prospective study
89 Ratti PL. Una fotografia con EEG ad alta densità degli eventi parasonnici NREM nei disturbi dell’arousal
105 Silvani A. Manconi M. Physiological time structure of the tibialis anterior motor activity during sleep in mice, rats and humans
118 Vinai P. Manconi M. New data on psychological traits and sleep profiles of patients affected by nocturnal eating
91 Ripellino P. Studio osservazionale delle complicanze neurologiche in corso di infezione acuta da epatite E (NeuroCAVE)
95 Sacco L. Comparative value of [(123)I]-FP-CIT SPECT and [(123)I]-MIBG myocardial scintigraphy in distinguishing between dementia with Lewy bodies and other types of dementia
111 Trendafilov V. Synaptic homeostasis in Parkinson’s disease: a high-density EEG study in different stage of the disease
19 Cereda C. A benchmarking tool that evaluates computer tomography perfusion infarct core predictions against a DWI standard
 

11

Burgio F. RAMAN guided resection of Glioma using nanoparticles targeted cell recognition in the mouse model
Piffaretti D. RAMAN Spectroscopy enhanced imaging of Glioblastoma in Cell Culture and in Vivo Model
Sarti M. Characterization of new invasive glioblastoma xenograft mouse model to improve radical surgery into the marginal area
CARDIOCENTRO
Preclinica
1 Altomare C. Induced Pluripotent Stem (iPS) Cells to Assess Paracrine Properties of Exosomes Secreted by Cardiac Progenitors.
4 Andriolo G. Exosomes from human Cardiac Progenitor Cells: development of GMP-grade manufacturing and testing methods
22 Cervio E. Superior Exosome-mediated Paracrine Effects of Cardiac Progenitor Cells Compared to Bone Marrow Mesenchymal Stem Cells
37 De Jesus Da Cruz Monteiro B. Ex-Vivo Expansion of human Cardiac Biopsy-Derived Stem Cells in Serum Free Nutrient Media Supplemented With Growth Factors
39 Duarte Jorge S. Human Cardiac Biopsy-Derived Stem Cells: Ex-Vivo Expansion On Adhesion Substrates In Physico-Chemically Defined Nutrient Media.
40 Duarte Jorge S.Optimization Of Human Cardiac Biopsy-Derived Stem Cell Proliferation Using The Conditioned Medium.
10 Biemmi V. Characterization of Exosomes Secreted by Human Polarized Macrophages
77 Panella S. Towards a new xeno-free microcarrier-based cell culture system for the scalable expansion of hASCs
78 Panella S. A new serum-free medium to culture macrophages derived from peripheral blood monocytes
103 Scibona E. Growth and expansion of human adipose tissue-derived stem cells (hASC) as cells aggregates (spheroids)
Clinica
12 Capoferri M. Outcomes di una terapia cardioriabilitativa ambulatoriale sui fattori di rischio cardiovascolari e sui parametri funzionali
16 Cassina T. Fattori di rischio per insorgenza di delirium dopo impianto di protesi valvolare aortica trans-catetere (TAVI)
32 Corsi D. Outcome clinico in pazienti ultraottantenni operati in Canton Ticino di chirurgia mitralica
43 Ferrari E. Confronto dei risultati operatori dopo sostituzione valvolare aortica con bioprotesi standard o Intuity (a impianto rapido)
57 Grego S. Dissezione Aortica tipo A sottoposta a intervento cardiochirurgico. Epidemiologia dell’evento nel canton ticino
112 Trunfio R. Approccio multidisciplinare nella patologia aortica toracica urgente. Iportanza della sala ibrida.
61 Lavanco V. Mitral valve annulus geometry modifications before and after MitraClip
109 Tarascio M. Is speackle tracking deformation able to distinguish between transmural and subendocardial scar?
81 Pedrazzini G. Outcome in patients presenting with ACS and AF: single centre experience on 156 pts
82 Pedrazzini G. Incidence, distribution and outcome of occluded coronary arteries in patients presenting with acute coronary syndrome
83 Pedrazzini G. Sperimentazione di un apposito anello per riconoscere precocemente l’arresto cardiaco. Risultati preliminari su 76 pazienti
107 Sürder D. The 6 and 12 months results of the Swiss investigator-initiated prospective MitraClip® registry (MitraSwiss)
Elettrofisiologia
14 Caputo ML. Accuracy of ECG Classification of Left Bundle Branch Block in Heart Failure Patients: Insights from Intracardiac Ventricular Activation
28 Conte G. HIGH PROCEDURAL EFFICACY AND SAFETY OF CRYOBALLOON ABLATION OF PAROXYSMAL ATRIAL FIBRILLATION: A SINGLE-CENTRE EARLY EXPERIENCE
13 Caputo ML. Five years-experience of management of cardiac implantable electronic devices patients by remote monitoring
29 Conte G.SUBCUTANEOUS CARDIOVERTER-DEFIBRILLATOR IMPLANTATION IN DRUG-INDUCED BRUGADA SYNDROME
30 Conte G. SUBCUTANEOUS IMPLANTABLE-CARDIOVERTER DEFIBRILLATOR ELIGIBILITY BASED ON TEMPLATE ECG SCREENING: A SINGLE-CENTER EXPERIENCE
90 Regoli F. Sicurezza ed efficacia a medio-termine del defibrillatore cardiovertitore sottocutaneo (S-ICD)
Medicina Computazionale
27 Conte G. CHANGES IN P WAVE MORPHOLOGY AFTER PULMONARY VEIN ISOLATION: INSIGHTS FROM COMPUTER SIMULATIONS
53 Gharaviri A. Epicardial Fibrosis enhances endo-epicardial dissociation and breakthrough in an atrial computer model
63 Maffessanti F. Tessuto cicatriziale e potenziali endocardici: confronto tra mappaggio elettroanatomico e risonanza magnetica
85 Pezzuto S. Ricostruzione rapida dell’attivazione cardiaca tridimensionale mediante l’utilizzo di un efficiente solutore eiconale: primi risultati
97 Sánchez C. Prolonged Trans-septal Delay Is The Prevalent Conduction Disease In Left-Bundle-Branch Block: Insight From Patient-specific Models

6° Giornata della Ricerca Clinica della Svizzera Italiana – 18 marzo 2016

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18/03/2016

All Day

Location
Palazzo dei Congressi Lugano

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